Which of these events does not occur in the year 1616?

The defenestration of Prague refers to a historical event that took place in 1618, when several Catholic officials were thrown out of a window by Protestant nobles. This event was significant as it marked the beginning of the Thirty Years' War in Bohemia. Thus, it did not occur in 1616.

In contrast, Pocahontas's journey to England did occur in 1616 when she traveled to London, where she met King James I. William Shakespeare passed away in 1616 as well, with his death occurring on April 23 of that year. Squanto, the Native American figure known for assisting the Pilgrims, returned to America in 1614 but played a significant role in helping the Pilgrims a couple of years later. Therefore, while the other events are accurately dated to that time period, the defenestration of Prague is the only one that did not happen in 1616.